Latest updates to Prodigy (formerly CKS)

January 13, 2012 at 10:29 am Leave a comment

The following PRODIGY topics have been updated to include new evidence and recommendations published by the Medicines and Healthcare products Regulatory Agency (MHRA), the National Institute for Health and Clinical Excellence (NICE), manufacturers’ summary of product characteristics (SPC), the British National Formulary (BNF) and the Driver and Vehicle Licensing Agency (DVLA).
    • Information about a possible interaction between pantoprazole and warfarin from the manufacturer’s SPC.
    • Information about the potentially serious interaction between proton pump inhibitors and protease inhibitors (atazanavir and saquinavir) from the BNF.
  • Bipolar disorder and Schizophrenia have been updated to include relevant information from the MHRA about a risk of extra-pyramidal effects or withdrawal symptoms (or both) in newborns after maternal use of anti-psychotics during the third trimester of pregnancy has been added to this topic.
  • Dementia has been updated to include prescribing information for memantine, and the Basis of Recommendation has been updated to reflect the most recent considerations of the NICE regarding memantine.
  • Depression and Menopause have been updated to include:
    • Updated information from the manufacturer’s SPC that venlafaxine may alter glycaemic control in people with diabetes mellitus.
    • Information on new maximum doses, adverse effects, and drug interactions for citalopram and escitalopram following the publication of new safety data regarding the association of with dose-dependent QT interval prolongation by Lundbeck Ltd, in collaboration with the MHRA.
  • Depression – antenatal and postnatal and Obsessive-compulsive Disorder have been updated with information on new maximum doses, adverse effects, and drug interactions for citalopram and escitalopram following the publication of new safety data regarding the association of with dose-dependent QT interval prolongation by Lundbeck Ltd, in collaboration with the MHRA.
  • Diabetes – type 2 has been updated to include:
    • The MHRA warning on the interaction between systemic fusidic acid and statins.
    • Information on saxagliptin (Onglyza®) and linagliptin (Trajenta®), two new dipeptidyl peptidase-4 inhibitors licensed for the treatment of adults with type 2 diabetes to improve glycaemic control.
    • Information on liraglutide (Victoza®).
    • Information on fitness to drive from the DVLA’s guidance for medical practitioners, At a glance guide to the current medical standards of fitness to drive (2011).
    • A tabulated version of the treatment recommendations for blood glucose control, to aid navigation.
  • HIV infection and AIDS has been updated to include information about the potentially serious interaction between proton pump inhibitors and protease inhibitors (atazanavir and saquinavir) from the BNF.
A literature search was conducted in October 2011 to identify evidence-based guidelines, UK policy, systematic reviews, and key RCTs published since the last revision of the following topics:
  •  Adverse drug reactions – no changes to clinical recommendations have been made.
  •  Angio-oedema and anaphylaxis – recommendations from the NICE guideline on Anaphylaxis: assessment to confirm an anaphylactic episode and the decision to refer after emergency treatment for a suspected anaphylactic episode (2011) have been included. In addition, the management section has been restructured to improve clarity and navigation.
  • Bites – human and animal – no changes to clinical recommendations have been made.
  • Urticaria – recommendations on managing people who have had an inadequate response to the standard licensed dose of antihistamine have been changed to include the option to double the standard licensed dose of the first choice antihistamine, before considering referral to secondary care for further management. In addition, the topic has been restructured to improve clarity and navigation.
Advertisements

Entry filed under: Uncategorized.

Pop up Library service NHS User Survey 2011 – Results

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Trackback this post  |  Subscribe to the comments via RSS Feed


Contact Us

St. George's Library 1st Floor Hunter Wing St. George's, University of London Cranmer Terrace SW17 ORE Tel: 020 8725 5433 Email: kjohn@sgul.ac.uk

RSS National Electronic Library for Medicines

  • An error has occurred; the feed is probably down. Try again later.
Feed on Posts

Twitter Updates


%d bloggers like this: